Dear all, I would be grateful if any of professional friends share this reference with us. We need this reference very urgently. Thanks in advance. http://www.future-science.com/doi/pdf/10.4155/fmc.10.21 Future Medicinal Chemistry June 2010, Vol. 2, No. 6, Pages 949-964 Title: *Strategies for discovering and derisking covalent, irreversible enzyme inhibitors* Author: *Douglas S Johnson†1, Eranthie Weerapana2 & Benjamin F Cravatt†2* Best Regards, --------------------------------------- Devandrappa T M Information Officer Dayananda Sagar College of Engineering Kumarswamy Layout Bangalore-560078 -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean.