Dear All, I am in need of following article. I request you all if any one having this please forward to me. Regards, J.Kasinathan Librarian #12, Poonamallee Road, Ekkattuthangal, Chennai 600 032 Email : jkasi1963@yahoo.co.in ------------------------------------------------------------------------- Journal Name : Journal of pharmaceutical science Title : Simutaneous determination of nitrate and nitrite in toothpaste by HPLC. Author : Lulla, H & Chen SS Vol/ Issue/ Year: V73/ 7/ Pages 1004 - 1006/ 1984 Publisher : Wiley Interscience Keywords Nitrate - simultaneous determination with nitrite, toothpastes, HPLC • Nitrite - simultaneous determination with nitrate, toothpastes, HPLC • Dentifrices - simultaneous determination of nitrate and nitrite, HPLC Abstract A stability-indicating analytical method is described for the simultaneous determination of nitrate, and if present, its reductive degradation product, nitrite, in toothpastes. Nitrate and nitrite were extracted from the toothpaste using distilled water and separated from other water-soluble excipients by two RP-8 columns (250 mm × 4 mm i.d.) using a mobile phase containing 0.2% (w/v) sodium acetate and 2.5% (v/v) glacial acetic acid in distilled water. A UV detector set at 313 nm was used for quantitation. The method was applied to commercial toothpastes containing 5% potassium nitrate and yielded an average recovery of 100.1% with a relative standard deviation of 1.43%. Average recovery of nitrate and nitrite from spiked samples were 100.6% and 96.4%, respectively. The minimum detectable concentration for nitrite was 50 g/g of toothpaste. . -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean.